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It is important to seek medical treatment immediately if you experience: Hyperpigmentation of the lower leg and ankle, meaning skin patches become darker than the normal surrounding skin Thickening and hardening of the skin in the same area that may itch and look red and scaly, similar to eczema A skin ulcer, which is a sore that appears red and may drain fluid or pus and is not caused by an injury These would be the most severe symptoms where urgent attention is needed, Dr

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however, its abilities to improve tpe 1 collagen and increase blood flow via angiogenesis means it is a powerful peptide for wound healing and overall regeneration following damage